一、基本信息
谢努力，副教授，硕士研究生导师。芙蓉计划卫生健康高层次人才，上海市“超级博士后”激励计划入选者。2014年和2019年分别获得湖南大学学士与博士学位，2020-2022年在上海交通大学化学化工学院开展博士后研究。以第一作者/通讯作者在JACS、Chem、ACS Nano、Adv. Sci.、Nano lett.、Anal. Chem.、Chem. Commun.等期刊发表论文十余篇，以第二作者身份发表Nature研究论文一篇。论文引用超2500余次。
参与《药剂学》、《药物分析》、《药剂学实验》等课程教学活动，曾获开云电竞信誉好教学质量优秀奖（本科），指导学生获得湖南省省级大学生创新训练项目1项。
联系方式：nulixie@csu.edu.cn
二、研究领域
1、基于自组装DNA纳米结构的智能药物递送与治疗研究
2、核酸纳米技术在癌症和其他疾病上的智能、精准诊断研究
3、核酸与金属相结合的纳米材料制备及其皮肤相关疾病治疗研究
三、教育&工作经历
2024.09-至今 开云电竞信誉好湘雅药学院 副教授
2023.01-2024.09 开云电竞信誉好湘雅药学院 讲师
2020.04-2022.12 上海交通大学化学化工学院 博士后 导师: 樊春海 院士
2017.10-2019.10 University of Michigan 联培博士 导师:Nicholas Kotov教授
2014.09-2019.12 湖南大学化学化工学院 博士 导师:黄晋 教授、王柯敏教授
2010.09-2014.06 湖南大学化学化工学院 学士
四、主持的科研项目
1、国家自然科学基金,青年C类项目，主持，在研
2、湖南省自然科学基金,青年基金项目,主持，结题
3、化学生物传感全国重点实验室开放基金，主持，在研
4、国家自然科学基金,重点项目，参与，结题
5、国家自然科学基金,面上项目，参与，结题
五、 代表成果
1. Zhen Tang, Yao Xiao, Nuli Xie*, Chenyun Sun, Mingqiang Li, Haitao Song, Kai Xia, Hui Lv, Jiang Li, Chunhai Fan, Fei Wang*. Directional long-distance signal transmission on two-dimensional DNA origami assemblies. Chem, 2026, 12, 102889.
2. Hanane Aliouat, Detian Zhang, Lanyuan Peng, Jiaxin Huang, Hongshi Cheng, Jiaojiao Zhu, Xiang Chen, Nuli Xie*, Wenhu Zhou*, Shuang Zhao*. Targeted DNA Nanomachine Enables Specific miRNA-Responsive Singlet Oxygen Amplification for Precise Cutaneous Squamous Cancer Therapy. Adv. Sci, 2025, 12, 2415296.
3. Shiyuan Liu, Jiaoli Wang, Yu Chen, Jiahao Fan, Bin Du, Ruiting Liu, Xiaobei Zhu, Kemin Wang, Nuli Xie*, Jin Huang*. Modular Assembled Localized Hybridization Chain Reaction for In Situ mRNA Amplified Imaging. Nano. Lett., 2024, 24, 37, 11590–11598.
4. Jing Wang, Nuli Xie, Shan Lu, Bo Xiao, Yangqin Ou, Qingnian Li, Dexian Liu, Wenhu Zhou*. CpG and Rutin Co‐Loaded DNA Tetrahedra for Targeted Therapy of Intracerebral Hemorrhage: Synergistic Hematoma Clearance and Neuroinflammation Inhibition. Adv. Funct. Matter. 2024, 34,2403469.
5. Hui Lv, Nuli Xie, Mingqiang Li, Mingkai Dong, Jiang Li, Xiaolei Zuo, Haibo Chen, Fei Wang*, Chunhai Fan*. Large-scale reconfigurable DNA-based logic gate for complex DNA computing. Nature 2023, 622, 292-300.
6. Zhenxiang Liu#, Nuli Xie#, Juan Li, Xiaoxiao Fu, Kemin Wang, Hui Shi*, Jin Huang*. Self-Priming DNA Polymerization-Propelled Stochastic Walkers on Magnetic Microbeads for Amplified Detection of miRNA. Anal. Chem. 2022, 95, 9, 4529-4535.
7. Nuli Xie, Huimin Wang, Xiaoxiao Fu, Jiaoli Wang, Jing Li, Kemin Wang, Jin Huang*. Dual amplification of bio-barcode and auto-cycling primer extension for highly sensitive detection of miRNA. Chem. Commun. 2022, 58, 73, 10221-10224.
8. Nuli Xie, Mingqiang Li, Yue Wang, Hui Lv, Jiye Shi, Jiang Li, Qian Li, Fei Wang*, Chunhai Fan. Scaling up multi-bit DNA full adder circuits with minimal strand displacement reactions. J. Am. Chem. Soc. 2022, DOI: 10.1021/jacs.2c03258.
9. Nuli Xie, Shiyuan Liu, Hongmei Fang, Yanjing Yang, Ke Quan, Jing Li, Xiaohai Yang, Kemin Wang, Jin Huang*. Three-dimensional molecular transfer from DNA nanocages to inner gold nanoparticle surfaces. ACS Nano 2019, 13, 4174-4182.
10. Nuli Xie, Haiyan Wang, Ke Quan, Feng Feng, Jin Huang*, Kemin Wang*. Self-assembled DNA-Based geometric polyhedrons: construction and applications. TrAC-Trends in Anal. Chem. 2020, 126, 115844.
11. Nuli Xie, Jin Huang*, Xiaohai Yang, Xiaoxiao He, Jianbo Liu, Jiaqi Huang, Hongmei Fang, Kemin Wang*. Scallop-inspired DNA nanomachine: a ratiometric nanothermometer for intracellular temperature sensing. Anal. Chem. 2017, 89, 12115-12122.
12. Nuli Xie, Jin Huang*, Xiaohai Yang, Yanjing Yang, Ke Quan, Min Ou, Hongmei Fang, Kemin Wang*. Competition-mediated FRET-switching DNA tetrahedron molecular beacon for intracellular molecular detection. ACS Sens. 2016, 12, 1445-1452.
13. Nuli Xie, Jin Huang*, Xiaohai Yang, Yanjing Yang, Ke Quan, He Wang, Le Ying, Min Ou, Kemin Wang*. A DNA tetrahedron-based molecular beacon for tumor-related mRNA detection in living cells. Chem. Commun. 2016, 52, 2346-2349.
14. Nuli Xie, Shiyuan Liu, Xiaohai Yang, Xiaoxiao He, Jin Huang*, Kemin Wang*. DNA tetrahedron nanostructures for biological applications: biosensors and drug delivery. Analyst 2017, 142, 3322-3332.
15. Le Ying #, Nuli Xie#, Yanjing Yang, Xiaohai Yang, Qifeng Zhou, Bincheng Yin, Jin Huang*, Kemin Wang*. A cell-surface-anchored ratiometric i-motif sensor for extracellular pH detection. Chem. Commun. 2016, 52, 7818-7821.
16. Hongmei Fang#, Nuli Xie#, Min Ou, Jin Huang, Wenshan Li, Qing Wang, Jianbo Liu, Xiaohai Yang*, Kemin Wang*. Detection of nucleic acids in complex samples via magnetic microbead-assisted catalyzed hairpin assembly and “DD-A” FRET. Anal. Chem. 2018, 90, 7164-7170.
热忱欢迎具有药学、化学、化学生物学等学科背景的研究生或本科生加入研究团队。
